Jul 16, 2025 · The knowledgebase automatically integrates gene-centric data from ~200 web sources, including genomic, transcriptomic, proteomic, genetic, clinical and functional information.

Jul 17, 2025 · This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride …

Jul 17, 2025 · The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins …

Jul 17, 2025 · This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a …

Jul 17, 2025 · The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell …

Jul 17, 2025 · The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix …

Jul 17, 2025 · Various mutations have been described for this gene and have been linked to human diseases related to impaired immune function such as severe combined …

Jul 17, 2025 · This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch …

Jul 17, 2025 · This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA.

Jul 17, 2025 · This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages.